Associate Scientist/ Scientist (Upstream Process Development)

Reference Number: 29873
Type of placement: Contract, 12 Months (extendable)
Location: CH, NW

Introduction:

Our client is a leading global player in the Pharmaceutical industry with global headquarters in Basel, Switzerland. They are undergoing a transformation with respect to culture and outside perception. The organisation focusses on novel therapies in Oncology and Ophthalmology and is also currently developing a world-leading pipeline in Neuroscience and Dermatology with one of the strongest pipelines of Phase II/III studies in the world. We are currently looking for an enthusiastic Associate Scientist/ Scientist to be based in Basel Switzerland for a 12 Months contract.

 As an ideal candidate you should be capable of supporting the improvement and intensification of cell culture processes for therapeutic protein manufacture as well as the evaluation of new technologies in this field.

Main Responsibilities:

  • Supporting the development of efficient, high-yield, robust and scalable fermentation processes for new biological entities;
  • Supporting the improvement and intensification of established fed-batch cell culture processes from vial break to harvest, including seed and main bioreactor stages;
  • Supporting the implementation and evolution of (semi-)continuous perfusion cell culture processes;
  • Supporting the evaluation and implementation of new equipment and technologies in the USP environment;
  • Planning and performing parallelized cell culture experiments at lab scale (small to bench-top);
  • Supporting NBE development within the Early Phase Development (EPD) Unit, with supervision and guidance from functional experts of the drug substance development teams;
  • Working in multidisciplinary and international teams, reporting technical/experimental results to the functional lead in USP development;
  • Working at the interface to related drug substance process development and analytical functions;
  • Designing, planning and executing USP lab activities, primarily parallel fermentation experiments, in the lab scale facility using state of the art disposable and glass bioreactor technology;
  • Recording experimental data in the respective data management systems;
  • Evaluating/interpreting and presenting results to the functional experts and USP development team;
  • Contributing to the evaluation and implementation of new scientific technologies/equipment;
  • Identifying and realizing opportunities for laboratory and process improvements;
  • Proactively communicating issues and any critical observations in a timely manner to the appropriate management level and/or relevant project team member(s);
  • Taking care of USP laboratory equipment.

Qualifications and Experience:

  • Bachelor/ Masters of Science in Life Sciences (e.g. Biotechnology, Biochemistry or Bioengineering) with basic or profound knowledge in upstream processing or equivalent education/experience;
  • Basic laboratory experience with cell cultures (i.e. aseptic handling of cells) or broad experience in upstream processing with mammalian cell cultures (preferably with shake flasks, wave and stirred bioreactors);
  • Intrinsic curiosity, willingness to adopt challenging tasks and grow in related areas of expertise (e.g. parallelized, automated fermentation);
  • Fluency in English, German would be a distinct advantage;
  • Relevant working/residency permit or Swiss/EU-Citizenship required.

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